Plant Sciences - Publications

Permanent URI for this collection

https://dspace.uohyd.ac.in/handle/1/112

Browse

Browsing Plant Sciences - Publications by Author "Ahmed, Anees"
  • Item
    Chaperone Like Attributes of Biogenic Fluorescent Gold Nanoparticles: Potential to Alleviate Toxicity Induced by Intermediate State Fibrils Against Neuroblastoma Cells
    ( 2019-11-19) Mujeeb, Anzar Abdul ; Alam, Khan Farheen Badre ; Alshameri, Ansam Wadia Faid ; Jamal, Fauzia ; Farheen, Saba ; Kashif, Mohd ; Ahmed, Anees ; Ghazi, Irfan Ahmad ; Owais, Mohammad
    In general, neurodegenerative disorders have a great deal of correlation with the misfolded as well as aggregated forms of protein-based macromolecules. Among various species formed during the aggregation process, protein oligomers have been classified as most toxic entities against several types of living cells. A series of chemicals have been developed to inhibit protein aggregation as a measure to regulate neurodegenerative diseases. Recently, various classes of nanoparticles have also been reported to inhibit protein aggregation. In the present study, we synthesized fluorescent gold nanoparticles (B-AuNPs) employing Olax scandens leaf extract. Next, an in vitro study was performed to assess the effect of as-synthesized B-AuNPs on the aggregation behavior of the ovalbumin (OVA) and other related model proteins. We performed an extensive study to elucidate anti-amyloidogenic properties of nano-sized entities and established that small-sized B-AuNPs manifest chaperone potential against protein aggregation. Further, we exploited as-synthesized B-AuNPs as a mean to prevent protein aggregation mediated toxicity in neuroblastoma cells.