Carbohydrates as Chiral Auxiliaries in Asymmetric Darzens Reactions: Enantioselective Synthesis of the Benzothiazepine Ring System of Diltiazem
Carbohydrates as Chiral Auxiliaries in Asymmetric Darzens Reactions: Enantioselective Synthesis of the Benzothiazepine Ring System of Diltiazem
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Date
1996-07-01
Authors
Nangia, Ashwini
Rao, P. Bheema
Madhavi, N. N.L.
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Abstract
Darzens condensation of a dihydroglucal chloro ester 18 with p-anisaldehyde affords diastereoisomeric glycidic esters 20,21 which are elaborated to the benzothiazepinone ring system 25 of diltiazem 1.
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Journal of Chemical Research - Part S