Phages specific for mycobacterial lipoarabinomannan help serodiagnosis of tuberculosis

dc.contributor.author	Bua, Alessandra
dc.contributor.author	Rosu, Valentina
dc.contributor.author	Molicotti, Paola
dc.contributor.author	Das Gupta, Sujoy K.
dc.contributor.author	Ahmed, Niyaz
dc.contributor.author	Zanetti, Stefania
dc.contributor.author	Sechi, Leonardo A.
dc.date.accessioned	2022-03-27T05:17:09Z
dc.date.available	2022-03-27T05:17:09Z
dc.date.issued	2009-07-01
dc.description.abstract	This study evaluated the possibility to use six phages specific to the Mycobacterium tuberculosis lipoarabinomannan (LAM) as tools for tubercular serodiagnosis. We analysed sera samples from 30 subjects with active tuberculosis (TB+), 30 with latent tubercular infection (LTBI) and 60 healthy subjects as controls (K). Our data indicated a good antibody response of the TB+ and LTBI patients against the phage Ri(7)17; the optical density (OD) values obtained from sera patients was statistically significant when compared to the control samples. Our results confirm that phage display technology might be useful to develop new tools for diagnosis of tuberculosis.
dc.identifier.citation	New Microbiologica. v.32(3)
dc.identifier.issn	11217138
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/7804
dc.subject	LTBI (latent TB infection)
dc.subject	Mycobacterium tuberculosis
dc.subject	Tubercular serodiagnosis
dc.title	Phages specific for mycobacterial lipoarabinomannan help serodiagnosis of tuberculosis
dc.type	Journal. Article
dspace.entity.type

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