Single-Step Synthesis of 3-Iodoquinolines from 2-Aminophenyl Ketones through a Regioselective (6-endo-dig) Electrophilic Cyclization

dc.contributor.author	Yaragorla, Srinivasarao
dc.contributor.author	Pareek, Abhishek
dc.contributor.author	Dada, Ravikrishna
dc.contributor.author	Saini, Pyare Lal
dc.date.accessioned	2022-03-27T08:49:42Z
dc.date.available	2022-03-27T08:49:42Z
dc.date.issued	2017-08-24
dc.description.abstract	A highly facile single-step synthetic approach to 3-iodoquinolines has been developed for the first time from readily available 2-aminobenzophenones and terminal alkynes. The reaction involves the nucleophilic addition of terminal alkynes to 2-aminobenzophenones followed by a regioselective iodocyclization (6-endo-dig) to furnish 2,4-disubstituted 3-iodoquinolines in high yields. In general, 2,4-diaryl-substituted products were isolated without the need for column chromatography.
dc.identifier.citation	European Journal of Organic Chemistry. v.2017(31)
dc.identifier.issn	1434193X
dc.identifier.uri	10.1002/ejoc.201700668
dc.identifier.uri	https://onlinelibrary.wiley.com/doi/10.1002/ejoc.201700668
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/11884
dc.subject	Cross-coupling
dc.subject	Cyclization
dc.subject	Iodine
dc.subject	Nitrogen heterocycles
dc.subject	Regioselectivity
dc.title	Single-Step Synthesis of 3-Iodoquinolines from 2-Aminophenyl Ketones through a Regioselective (6-endo-dig) Electrophilic Cyclization
dc.type	Journal. Article
dspace.entity.type

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