P-TsOH Promoted Au(I)-Catalyzed Consecutive Endo Cyclization of Yne-Tethered Ynamide: Access to Benzofused Dihydroisoquinolones

dc.contributor.author	Nayak, Sanatan
dc.contributor.author	Ghosh, Nayan
dc.contributor.author	Prabagar, B.
dc.contributor.author	Sahoo, Akhila K.
dc.date.accessioned	2022-03-27T08:33:43Z
dc.date.available	2022-03-27T08:33:43Z
dc.date.issued	2015-11-20
dc.description.abstract	A novel synthetic route to benzo[f]dihydroisoquinolone through a p-TsOH promoted cascade cyclization of easily accessible diyne-tethered ynamides in the presence of a Au(I)-catalyst is described. This reaction unveils a broad substrate scope, constructing a wide range of benzo[f]dihydroisoquinolones in good yields. The diyne-tethered ynamides are synthesized from inexpensive o-iodoaniline through Sonogashira couplings and the Cu-mediated C-N bond formation. The role of p-TsOH is examined, and the reaction pathway is also deduced. The benzo[f]isoquinoline scaffold is constructed from benzo[f]dihydroisoquinolones.
dc.identifier.citation	Organic Letters. v.17(22)
dc.identifier.issn	15237060
dc.identifier.uri	10.1021/acs.orglett.5b02946
dc.identifier.uri	https://pubs.acs.org/doi/10.1021/acs.orglett.5b02946
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/10771
dc.title	P-TsOH Promoted Au(I)-Catalyzed Consecutive Endo Cyclization of Yne-Tethered Ynamide: Access to Benzofused Dihydroisoquinolones
dc.type	Journal. Article
dspace.entity.type

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