The Baylis-Hillman reaction: One-pot stereoselective synthesis of methyl (2E)-3-aryl-2-hydroxymethylprop-2-enoates
The Baylis-Hillman reaction: One-pot stereoselective synthesis of methyl (2E)-3-aryl-2-hydroxymethylprop-2-enoates
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Date
2000-01-01
Authors
Basavaiah, D.
Padmaja, K.
Satyanarayana, T.
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Abstract
A facile, simple and one-pot conversion of methyl 3-aryl-3-hydroxy-2-methylenepropanoates into methyl (2E)-3-aryl-2-hydroxymethylprop-2-enoates via the sequential treatment with acetic anhydride/trimethylsilyl trifluoromethanesulfonate (TMSOTf) and potassium carbonate/methanol is described.
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Keywords
Baylis-Hillman reaction,
Methyl (2E)-3-aryl-2-hydroxymethylprop-2-enoates,
One-pot stereoselective synthesis,
Trimethylsilyl trifluoromethanesulfonate (TMSOTf)
Citation
Synthesis