Anti-HIV activity of a glycoprotein from first trimester placental tissue
Anti-HIV activity of a glycoprotein from first trimester placental tissue
| dc.contributor.author | Kondapi, Anand K. | |
| dc.contributor.author | Hafiz, M. A. | |
| dc.contributor.author | Sivaram, T. | |
| dc.date.accessioned | 2022-03-27T05:16:19Z | |
| dc.date.available | 2022-03-27T05:16:19Z | |
| dc.date.issued | 2002-01-01 | |
| dc.description.abstract | Human Immunodeficiency Virus-1 (HIV-1) transmission from a mother to the offspring during pregnancy is highly complex and a variable process in part due to the presence of several anti-HIV factors. In this study, we report an early pregnancy-associated protein (early pregnancy associated protein-1, Epap-1) with an apparent molecular weight of 90 kDa in placental tissue of pregnant women during the first trimester. Epap-1 was isolated and purified using Sambucus nigra agarose lectin affinity chromatography. Epap-1 strongly inhibits HIV-1MN, HIV-191US056, HIV-1VB-7 replication in vitro while it exhibits low activity with HIV-1VB-66 strain. The molecular analysis of action of Epap-1 shows that it affects HIV-CD4 binding through inhibition of CD4-gp120 interaction. © 2002 Elsevier Science B.V. All rights reserved. | |
| dc.identifier.citation | Antiviral Research. v.54(1) | |
| dc.identifier.issn | 01663542 | |
| dc.identifier.uri | 10.1016/S0166-3542(01)00212-1 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0166354201002121 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/7600 | |
| dc.subject | Anti-HIV activity | |
| dc.subject | Early pregnancy associated protein | |
| dc.subject | gp120-CD4 interaction | |
| dc.subject | Pregnancy | |
| dc.title | Anti-HIV activity of a glycoprotein from first trimester placental tissue | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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