AM1 study of structure-activity relationships in bicyclic aza-β-lactams
AM1 study of structure-activity relationships in bicyclic aza-β-lactams
| dc.contributor.author | Nangia, A. | |
| dc.contributor.author | Chandrakala, P. S. | |
| dc.contributor.author | Balaramakrishna, M. V. | |
| dc.contributor.author | Latha, T. V.A. | |
| dc.date.accessioned | 2022-03-27T09:35:43Z | |
| dc.date.available | 2022-03-27T09:35:43Z | |
| dc.date.issued | 1995-11-10 | |
| dc.description.abstract | AM1 calculations on bicyclic aza-β-lactams 4 (1,3-diazetidin-2-ones) are carried out to investigate the effect of ring size (five versus six), position of olefin (Δ2 versus Δ3), and electronegative atom (oxygen) in the tethered non-β-lactam ring on the structure of diazetidinone. The results are discussed in terms of structural trends related to β-lactamase and transpeptidase inactivation capability. The biological activity of novel aza-β-lactams 4 is comparable to that of β-lactams 3. © 1995. | |
| dc.identifier.citation | Journal of Molecular Structure: THEOCHEM. v.343(C) | |
| dc.identifier.issn | 01661280 | |
| dc.identifier.uri | 10.1016/0166-1280(95)90547-2 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/0166128095905472 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/13093 | |
| dc.title | AM1 study of structure-activity relationships in bicyclic aza-β-lactams | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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