Reusable directing groups [8-aminoquinoline, picolinamide, sulfoximine] in C(sp < sup > 3 < /sup > )-H bond activation: Present and future

Abstract

This report briefly discusses the reusable directing group assisted functionalization of unactivated remote alkyl C-H bonds and their synthetic potential in organic chemistry. The challenges involved for the functionalization of inert alkyl C-H bonds is highlighted. With the strong impact of C-H activation, we believe this report would boost researchers unraveling novel methods for the chemo-, regio-, and stereoselective activation of unbiased C(sp3)-H bonds and their potential utility for the rapid synthesis of complex molecular entities.