The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers

dc.contributor.author	Kiran, Shashi
dc.contributor.author	Dar, Ashraf
dc.contributor.author	Singh, Samarendra K.
dc.contributor.author	Lee, Kyung Yong
dc.contributor.author	Dutta, Anindya
dc.date.accessioned	2022-03-27T04:56:33Z
dc.date.available	2022-03-27T04:56:33Z
dc.date.issued	2018-12-06
dc.description.abstract	The oncogenes E6 and E7 from high-risk HPVs induce many cancers. Kiran et al. show that the E6 protein from oncogenic HPV associates with USP46 and directs USP46 to deubiquitinate and stabilize cellular proteins like Cdt2 to promote cell proliferation and tumor growth, making USP46 an attractive target for therapy.
dc.identifier.citation	Molecular Cell. v.72(5)
dc.identifier.issn	10972765
dc.identifier.uri	10.1016/j.molcel.2018.09.019
dc.identifier.uri	https://www.sciencedirect.com/science/article/abs/pii/S1097276518307901
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/7583
dc.subject	Cdt2
dc.subject	cervical cancer
dc.subject	deubiquitinase
dc.subject	E6
dc.subject	HPV
dc.subject	oncogenic virus
dc.subject	USP46
dc.title	The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers
dc.type	Journal. Article
dspace.entity.type

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