Gene regulatory networks directing cell fates within the hematopoietic system

Abstract

We review a new developmental framework for the hierarchical relationships among the various lineages of the hematopoietic system in the context of the underlying gene regulatory networks that orchestrate distinct cell fates. These regulatory networks or circuits comprise of transcription factors, chromatin modifying complexes and miRNAs. Molecular principles and mechanisms of action underlying the functions of such regulatory molecules in the activation and repression of alternate lineage gene expression programs are emphasized. Finally, we discuss mathematical models that can be used to gain an analytical appreciation of the architectures of gene regulatory networks and their developmental dynamics. © 2009 by Nova Science Publishers, Inc. All rights reserved.