A novel and green protocol for two-carbon homologation: A direct amino acid/K < inf > 2 < /inf > CO < inf > 3 < /inf > -catalyzed four-component reaction of aldehydes, active methylenes, Hantzsch esters and alkyl halides
A novel and green protocol for two-carbon homologation: A direct amino acid/K < inf > 2 < /inf > CO < inf > 3 < /inf > -catalyzed four-component reaction of aldehydes, active methylenes, Hantzsch esters and alkyl halides
No Thumbnail Available
Date
2006-01-30
Authors
Ramachary, Dhevalapally B.
Kishor, M.
Ramakumar, K.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
A novel and green approach for the two-carbon homologation of aldehydes using amino acid catalysis has been developed and further extended to the generation of pharmaceutically active cyano-esters via four-component reactions in one-pot. © 2005 Elsevier Ltd. All rights reserved.
Description
Keywords
Amino acids,
Hantzsch ester,
Multi-component reactions,
Organocatalysis,
Two-carbon homologation
Citation
Tetrahedron Letters. v.47(5)