Phosphoribosyltransferase superfamily: A comparative structural analysis

dc.contributor.author	Campillo, Nuria
dc.contributor.author	Nagarajaram, Hampapathalu A.
dc.contributor.author	Ghosh, Indira
dc.date.accessioned	2022-03-27T02:07:24Z
dc.date.available	2022-03-27T02:07:24Z
dc.date.issued	2001-12-01
dc.description.abstract	Purine phosphoribosyltransferases are members of a group of enzymes that are responsible for the formation of purine, pyrimidine and pyridine nucleotides. One feature of this family is a flexible loop, which is involved in the catalytic mechanism. This loop is variable both in sequence and structure in the phosphoribosyltransferase family. This paper describes the modelling and validation of a model of Plasmodium falciparum hypoxanthine-guanidine- phosphoribosyltransferase in an open conformation. A comparison of this model with 3D-structures of other members of the phosphorybosyltransferase family has allowed an assessment of the role of the open and closed conformations of the loop in the catalytic mechanism.
dc.identifier.citation	Journal of Molecular Modeling. v.7(4)
dc.identifier.issn	16102940
dc.identifier.uri	10.1007/S008940000001
dc.identifier.uri	http://link.springer.com/10.1007/s008940000001
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/4712
dc.subject	Comparative modelling
dc.subject	Phosphoribosyltransferase superfamily
dc.subject	Plasmodium falciparum
dc.subject	Sequence alignment
dc.title	Phosphoribosyltransferase superfamily: A comparative structural analysis
dc.type	Journal. Article
dspace.entity.type

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