Copper-catalyzed hydroarylation of alkynes for the synthesis of fascaplysin, rutacarpine and granulatimide analogues

Abstract

An efficient copper-catalyzed π-activation protocol has been developed for the intramolecular hydroarylation of alkynes. The strategy has been used in atom-economical syntheses of β-carboline analogues. The cycloisomerized products were obtained in moderate to good yields.