Cocrystals of 1,3,5-cyclohexanetricarboxylic acid with 4,4′ -bipyridine homologues: Acid⋯pyridine hydrogen bonding in neutral and ionic complexes

Abstract

cis,cis-1,3,5-Cyclohexanetricarboxylic acid (H3CTA) is crystallized with bipyridine bases 1,2-bis(4-pyridyl)ethane (bipy-eta), 1,4-bis(4-pyridyl-2-ethyl)benzene (bipy-etabz), 1,2-bis(4-pyridyl)ethylene (bipy-ete), and 1,4-bis(2-(4-pyridyl)ethenyl)benzene (bipy-etebz) to afford molecular complexes (H3CTA)·(bipy-eta)1.5 1, (H3CTA)· (bipy-etabz) 2, (H2CTA-)-(bipy-ete2H +)0.5 3, and (H2CTA-)· (bipy-etebz2H+)0.5 4. Cocrystal 1 has a super honeycomb hydrogen bond network stabilized by carboxylic acid-bipyridine O-H⋯N synthon Va. The hexagonal cavity of 34.1 × 36.7 Å is filled by parallel triple interpenetration of independent networks. 2 has zigzag chains of synthon Va connected via O-H⋯O hydrogen bonds. Carboxylic acid to pyridine proton transfer occurs in 3 and 4. These structures have undulated and flat 2D layers of O-H⋯O- and O-H⋯O hydrogen bonds that are connected to bipyridinium via N+-H⋯O- hydrogen bond Vb. H2CTA- anions in 4 form a porous parquet grid of 14.5 × 7.5 Å with the channels accommodating two molecules of bipy-etebz2H+. Supramolecular organization and 3D architecture in H3CTA crystal structures is compared with bipyridine adducts of trimesic acid.