Resolution of C < inf > 2 < /inf > -symmetric 9,10-dihydro-9,10-ethanoanthracene- 11,12- dicarboxylic acid and 2,3-diphenylsuccinic acid using (S)-proline

Abstract

Racemic 9,10-dihydro-9, 10-ethanoanthracene- 11,12-dicarboxylic acid is resolved to obtain the corresponding (S,S)-isomer in 96±2%, cc and the (R,R)-isomer in 97 ± 2% ee through complexation with (S)-proline in methanol. The racemic 2,3-diphenylsuccinic acid has been resolved to obtain the (S,S)-isomer in 93% ee using (S)-proline in methanol.