Transition metal mediated construction of pyrrole ring on 2,3-dihydroquinolin-4(1H)-one: Synthesis and pharmacological evaluation of novel tricyclic heteroarenes

Abstract

A facile two-step method for the construction of fused pyrrole ring leading to 5-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ones via C-C followed by intramolecular C-N bond forming reaction is described. In vitro pharmacological evaluation and molecular modelling studies of some of the compounds synthesized are presented. © 2011 The Royal Society of Chemistry.