Baylis-Hillman Acetates in Synthesis: Copper(I)/tert-Butyl Hydroperoxide Promoted One-Pot Oxidative Intramolecular Cyclization Protocol for the Preparation of Pyrrole-Fused Compounds and the Formal Synthesis of (±)-Crispine A

dc.contributor.author	Basavaiah, Deevi
dc.contributor.author	Lingaiah, Balthu
dc.contributor.author	Reddy, Guddeti Chandrashekar
dc.contributor.author	Sahu, Bharat Chandra
dc.date.accessioned	2022-03-27T09:00:49Z
dc.date.available	2022-03-27T09:00:49Z
dc.date.issued	2016-05-01
dc.description.abstract	A convenient one-pot protocol for the synthesis of benzo-fused and indole-fused indolizines from Baylis-Hillman acetates was developed. This strategy involves CuBr/tert-butyl hydroperoxide promoted oxidation, intramolecular cyclization, and aromatization as key steps. The efficacy of this methodology was demonstrated by the formal synthesis of (±)-crispine A, a biologically active molecule.
dc.identifier.citation	European Journal of Organic Chemistry. v.2016(14)
dc.identifier.issn	1434193X
dc.identifier.uri	10.1002/ejoc.201600384
dc.identifier.uri	https://onlinelibrary.wiley.com/doi/10.1002/ejoc.201600384
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/12265
dc.subject	Alkylation
dc.subject	Cyclization
dc.subject	Fused-ring systems
dc.subject	Nitrogen heterocycles
dc.subject	Oxidation
dc.title	Baylis-Hillman Acetates in Synthesis: Copper(I)/tert-Butyl Hydroperoxide Promoted One-Pot Oxidative Intramolecular Cyclization Protocol for the Preparation of Pyrrole-Fused Compounds and the Formal Synthesis of (±)-Crispine A
dc.type	Journal. Article
dspace.entity.type

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