Rubrivivaxin, a new cytotoxic and cyclooxygenase-I inhibitory metabolite from Rubrivivax benzoatilyticus JA2
Rubrivivaxin, a new cytotoxic and cyclooxygenase-I inhibitory metabolite from Rubrivivax benzoatilyticus JA2
| dc.contributor.author | Kumavath, Ranjith N. | |
| dc.contributor.author | Ramana, Ch V. | |
| dc.contributor.author | Sasikala, Ch | |
| dc.date.accessioned | 2022-03-27T03:45:52Z | |
| dc.date.available | 2022-03-27T03:45:52Z | |
| dc.date.issued | 2011-01-01 | |
| dc.description.abstract | A new phenol terpenoid ester metabolite was isolated from the culture supernatant of Rubrivivax benzoatilyticus JA2 when the organism grown on L-phenylalanine as sole source of nitrogen under photoheterotrophic condition. The compound was characterized by HPLC, LCMS, IR, NMR (1H, 13C) and Mass spectrometry, as a 3, 4-dihydroxybenzoyl-terpenoid ester [IUPAC: 3, 4-dihydroxy, 5-carboxy, 3-methylpentyl ester], which has a molecular mass (m/z) of 298 and we designated as rubrivivaxin. The significance of cyclooxygenase-I (COX-I) inhibitory, antimicrobial, cytotoxic activities against U937 (Human leukemic monocyte lymphoma) and Jurkat (T lymphocyte) cell lines conferred by rubrivivaxin. © 2010 Springer Science+Business Media B.V. | |
| dc.identifier.citation | World Journal of Microbiology and Biotechnology. v.27(1) | |
| dc.identifier.issn | 09593993 | |
| dc.identifier.uri | 10.1007/s11274-010-0420-9 | |
| dc.identifier.uri | http://link.springer.com/10.1007/s11274-010-0420-9 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/5292 | |
| dc.subject | Antimicrobial | |
| dc.subject | Cyclooxygenase | |
| dc.subject | Cytotoxicity | |
| dc.subject | Rubrivivax benzoatilyticus JA2 | |
| dc.subject | Rubrivivaxin | |
| dc.title | Rubrivivaxin, a new cytotoxic and cyclooxygenase-I inhibitory metabolite from Rubrivivax benzoatilyticus JA2 | |
| dc.type | Journal. Article | |
| dspace.entity.type |
Files
License bundle
1 - 1 of 1