Synthesis and characterization of advanced multifunctional magnetic nanoparticles for biomedical applications

Abstract

Magnetic nanoparticles (MNPs) have potential applications in the various biomedical fields including anticancer drug delivery, magnetic resonance imaging (MRI), destruction of the tumor via hyperthermia, bio-separation, catalysis, etc. Development of multifunctional magnetic nanoparticles (MFMNPs) could significantly expand the properties of existing magnetic nanoparticles as it combines many different functionalities in a single platform which make them suitable candidates to achieve simultaneous diagnosis and therapy for cancer treatment. Particularly, the design and synthesis of MFMNPs is an extremely focused and dynamic area of present biomedical research because of their potentials applications in targeted drug delivery, multimodal imaging, hyperthermia, photothermal therapy etc. Different combinations of functional materials with different size and shape have been explored to develop MFMNPs based nanocarriers aiming to enhance the effectiveness and safety of anticancer drugs. In this thesis, preparation, characterization and biomedical applications of various advanced multifunctional magnetic nanoparticles have been discussed. First, different types of MNPs have been synthesized and characterized. Then, different multifunctional nanocomposites nanoparticles such as NZF@Alb, Fe3O4@Alb, CF@Alb, mSiO2- CaFe2O4@P(Nipam-Aa), mesoCaCO3@CaFe2O4, NZF@mSiO2, NZF@mSiO2-CuS- PEG, NZF/Zn0.95Ni0.05O, NZF/Zn0.95Ni0.05O-mSiO2, mesoCaFe2O4 NPs, mSiO2@AgNPs and mSiO2@Ag-Fe3O4@P(Nipam) have been prepared. The structural, morphological, thermal, optical, magnetic properties and drug loading/release behaviour as well as biocompatibility/cytotoxicity of prepared multifunctional magnetic nanoparticles have been investigated. Anticancer activities of prepared anticancer drug-loaded multifunctional nano-formulations have been studied against Hela cells. Obtained results show that the present study could be extremely useful for the advancement of multifunctional magnetic nanocarrier’s design and development for biomedical applications.