Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study
Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study
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Date
2019-01-01
Authors
Allu, Suryanarayana
Suresh, Kuthuru
Bolla, Geetha
Mannava, M. K.Chaitanya
Nangia, Ashwini
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Abstract
The stronger sulfonamide-pyridine (SO2NH2...N-Py) and sulfonamide-carboxamide (SO2NH2...O═C-NH) hydrogen bonds direct the formation of cocrystals, while the weaker sulfonamide-amine (SO2NH2...N-H) hydrogen bond results in coamorphous products. IDP-PIP and IDP-ARG coamorphous solids exhibit remarkable stability under accelerated conditions.
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CrystEngComm. v.21(13)