Easy and stereoselective synthesis of cyclopropyl-substituted phosphonates via α-chlorophosphonates

dc.contributor.author	Kumara Swamy, K. C.
dc.contributor.author	Pavan Kumar, K. V.P.
dc.contributor.author	Rama Suresh, R.
dc.contributor.author	Satish Kumar, N.
dc.date.accessioned	2022-03-27T09:53:11Z
dc.date.available	2022-03-27T09:53:11Z
dc.date.issued	2007-05-16
dc.description.abstract	A facile stereoselective synthesis of cyclopropylphosphonates from the reaction of inexpensive α-chlorophosphonates with alkyl acrylates in the presence of sodium hydride is reported. Reaction with dimethyl maleate or fumarate also leads to cyclopropyl-substituted phosphonates. These reactions take place via Michael addition of acrylate, dimethyl maleate, or fumarate to the phosphonate carbanion, followed by expulsion of the chloride ion. © Georg Thieme Verlag Stuttgart.
dc.identifier.citation	Synthesis
dc.identifier.issn	00397881
dc.identifier.uri	10.1055/s-2007-966032
dc.identifier.uri	http://www.thieme-connect.de/DOI/DOI?10.1055/s-2007-966032
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/13405
dc.subject	Acrylates
dc.subject	Cyclopropanes
dc.subject	Diastereomers
dc.subject	Michael addition
dc.subject	Phosphonates
dc.title	Easy and stereoselective synthesis of cyclopropyl-substituted phosphonates via α-chlorophosphonates
dc.type	Journal. Article
dspace.entity.type

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