Discovery and protein engineering of biocatalysts for organic synthesis
Discovery and protein engineering of biocatalysts for organic synthesis
No Thumbnail Available
Date
2011-09-01
Authors
Behrens, Geoffrey A.
Hummel, Anke
Padhi, Santosh K.
Schätzle, Sebastian
Bornscheuer, Uwe T.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Modern tools for enzyme discovery and protein engineering substantially broadened the number of enzymes applicable for biocatalysis and helped to alter their properties such as substrate range, enantioselectivity, and stability under process conditions. In addition, these methods also enabled one to explore reactions for organic synthesis for which no suitable enzymes were available until recently. This review provides a summary of the different concepts and technologies, which are exemplified for various enzymes. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Description
Keywords
biocatalysis,
directed evolution,
enantioselectivity,
enzyme catalysis,
protein engineering,
rational protein design
Citation
Advanced Synthesis and Catalysis. v.353(13)