Synthesis of trans-1,2-diamines via sequential opening of cyclohexene oxide and aziridinium ions

dc.contributor.author	Periasamy, Mariappan
dc.contributor.author	Seenivasaperumal, Muthu
dc.contributor.author	Padmaja, Meduri
dc.contributor.author	Rao, Vutukuri Dharma
dc.date.accessioned	2022-03-27T09:09:03Z
dc.date.available	2022-03-27T09:09:03Z
dc.date.issued	2004-05-22
dc.description.abstract	A synthesis of trans-1,2-diaminocyclohexane derivatives via opening of cyclohexene oxide with secondary amines followed by preparation and opening of the corresponding aziridinium ions in situ by primary and secondary amines is described. Use of chiral α-methylbenzylamine for the opening of aziridinium ions gave a mixure of diastereomers that are readily separated by column chromatography. The C2 symmetric trans-1,2-bis (N-pyrrolidino)cyclohexane was resolved to obtain nonracemic samples that can be readily enriched by co-crystallization with fumaric acid to obtain enantiomerically pure compounds.
dc.identifier.citation	Arkivoc. v.2004(8)
dc.identifier.issn	14246376
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/12496
dc.subject	1,2-Amino alcohols
dc.subject	1,2-Diamines
dc.subject	Aziridinium ions
dc.subject	Resolution
dc.title	Synthesis of trans-1,2-diamines via sequential opening of cyclohexene oxide and aziridinium ions
dc.type	Journal. Article
dspace.entity.type

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