Facile formation of phosphono-acridanes via chloroacridines

Abstract

Novel bis-phosphonates bearing an acridane moiety are readily synthesized by the simple reaction of appropriate 9-chloroacridines with phosphites of the type (RO)2P(O)H. The by-product acridones could be converted back to the chloroacridines by treating them with thionyl chloride, and thus the effective yield is high. The structures of three bis-phosphonates are confirmed by X-Ray crystallography.