Iodocyclization of Propargyl Alcohols: Highly Facile Approach to Hetero/Carbocyclic Iodides

Abstract

Iodocyclization of propargyl alcohols is an active area for the construction of hetero/carbocyclic iodides. Ambiphilic reactivity of propargyl alcohols made it more attractive to tune their reactivity towards the development of regioselective synthetic strategies. In general, iodocyclization reactions are atom and step economic, promoted by simple and readily available inexpensive electrophilic iodine reagents at ambient temperature. These compounds find potential applications in pharmaceutical and material sciences, because of the presence of a preinstalled reactive iodide functionality. Therefore, many researchers are actively involved in developing synthetic strategies towards iodocyclizations from propargyl alcohols for various applications. In this mini-review, we emphasize the full list of synthetic endeavors made towards the “iodocyclization of propargyl alcohols, propargyl ethers and homopropargyl alcohols”.