Synthesis and resolution of 1-(α-pyrrolidinylbenzyl)-2-naphthol and its application in the resolution of 2,2 < sup > ′ < /sup > -dihydroxy-1,1 < sup > ′ < /sup > -binaphthyl
Synthesis and resolution of 1-(α-pyrrolidinylbenzyl)-2-naphthol and its application in the resolution of 2,2 < sup > ′ < /sup > -dihydroxy-1,1 < sup > ′ < /sup > -binaphthyl
| dc.contributor.author | Periasamy, Mariappan | |
| dc.contributor.author | Reddy, Meda Narsi | |
| dc.contributor.author | Anwar, Shaik | |
| dc.date.accessioned | 2022-03-27T09:09:01Z | |
| dc.date.available | 2022-03-27T09:09:01Z | |
| dc.date.issued | 2004-06-07 | |
| dc.description.abstract | 1-(α-Pyrrolidinylbenzyl)-2-naphthol 2 is easily prepared in 95% yield using benzaldehyde, 2-naphthol and pyrrolidine in ethanol at 78°C. It is resolved using inexpensive L-(+)-tartaric acid to obtain non-racemic samples that can be readily purified to enantiomeric purity through preparation of hydrogen bonded aggregates. The homochiral 1-(α-pyrrolidinylbenzyl)-2- naphthol 2 is useful in the resolution of racemic 2,2′- dihydroxy-1,1′-binaphthyl (BINOL) 3 via preparation of the corresponding diastereomeric borate complexes using B(OH)3. © 2004 Elsevier Ltd. All rights reserved. | |
| dc.identifier.citation | Tetrahedron Asymmetry. v.15(11) | |
| dc.identifier.issn | 09574166 | |
| dc.identifier.uri | 10.1016/j.tetasy.2004.04.030 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S095741660400312X | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/12495 | |
| dc.title | Synthesis and resolution of 1-(α-pyrrolidinylbenzyl)-2-naphthol and its application in the resolution of 2,2 < sup > ′ < /sup > -dihydroxy-1,1 < sup > ′ < /sup > -binaphthyl | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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