A facile one-pot transformation of baylis-hillman adducts into unsymmetrical disubstituted maleimide and maleic anhydride frameworks: A facile synthesis of himanimide A
A facile one-pot transformation of baylis-hillman adducts into unsymmetrical disubstituted maleimide and maleic anhydride frameworks: A facile synthesis of himanimide A
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Date
2010-02-15
Authors
Basavaiah, Deevi
Devendar, Badugu
Aravindu, Kunche
Veerendhar, Ainelly
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Abstract
Unsymmetrical, disubstituted maleimide and maleic anhydride frameworks have been accessed from Baylis-Hillman adducts in an operationally simple three-step (FriedelCrafts reaction, selective hydrolysis and cyclization), one-pot strategy. This strategy has been successfully extended to the synthesis of a representative bioactive compound, himanimide A (see scheme). (Chemical Equation Representation). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA,.
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Keywords
Friedel-crafts reaction,
Heterocycles himanimide a,
Natural products,
Synthetic methods
Citation
Chemistry - A European Journal. v.16(7)