Synthesis and in vitro anti-proliferative effects of 3-(hetero)aryl substituted 3-[(prop-2-ynyloxy)(thiophen-2-yl)methyl]pyridine derivatives on various cancer cell lines
Synthesis and in vitro anti-proliferative effects of 3-(hetero)aryl substituted 3-[(prop-2-ynyloxy)(thiophen-2-yl)methyl]pyridine derivatives on various cancer cell lines
| dc.contributor.author | Reddy Chamakura, Upendar | |
| dc.contributor.author | Sailaja, E. | |
| dc.contributor.author | Dulla, Balakrishna | |
| dc.contributor.author | Kalle, Arunasree M. | |
| dc.contributor.author | Bhavani, S. | |
| dc.contributor.author | Rambabu, D. | |
| dc.contributor.author | Kapavarapu, Ravikumar | |
| dc.contributor.author | Rao, M. V.Basaveswara | |
| dc.contributor.author | Pal, Manojit | |
| dc.date.accessioned | 2022-03-27T01:02:00Z | |
| dc.date.available | 2022-03-27T01:02:00Z | |
| dc.date.issued | 2014-03-01 | |
| dc.description.abstract | A series of 3-(hetero)aryl substituted 3-[(prop-2-ynyloxy)(thiophen-2-yl) methyl]pyridine derivatives were designed as potential anticancer agents. These compounds were conveniently prepared by using Pd/C-Cu mediated Sonogashira type coupling as a key step. Many of these compounds were found to be promising when tested for their in vitro anti-proliferative properties against six cancer cell lines. All these compounds were found to be selective towards the growth inhibition of cancer cells with IC50 values in the range of 0.9-1.7 μM (against MDA-MB 231 and MCF7 cells), comparable to the known anticancer drug doxorubicin. © 2014 Elsevier Ltd. All rights reserved. | |
| dc.identifier.citation | Bioorganic and Medicinal Chemistry Letters. v.24(5) | |
| dc.identifier.issn | 0960894X | |
| dc.identifier.uri | 10.1016/j.bmcl.2014.01.044 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0960894X14000742 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/3925 | |
| dc.subject | Alkyne | |
| dc.subject | Anti-proliferation | |
| dc.subject | Cancer | |
| dc.subject | Coupling | |
| dc.subject | Pd/C | |
| dc.title | Synthesis and in vitro anti-proliferative effects of 3-(hetero)aryl substituted 3-[(prop-2-ynyloxy)(thiophen-2-yl)methyl]pyridine derivatives on various cancer cell lines | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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