A thermostable transketolase evolved for aliphatic aldehyde acceptors
A thermostable transketolase evolved for aliphatic aldehyde acceptors
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Date
2015-01-11
Authors
Yi, Dong
Saravanan, Thangavelu
Devamani, Titu
Charmantray, Franck
Hecquet, Laurence
Fessner, Wolf Dieter
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Abstract
Directed evolution of the thermostable transketolase from Geobacillus stearothermophilus based on a pH-based colorimetric screening of smart libraries yielded several mutants with up to 16-fold higher activity for aliphatic aldehydes and high enantioselectivity ( > 95% ee) in the asymmetric carboligation step. This journal is
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Chemical Communications. v.51(3)