Synthetic studies on Ecteinascidin-743: synthesis of building blocks through Sharpless asymmetric dihydroxylation and aza-Michael reactions

dc.contributor.author	Chandrasekhar, S.
dc.contributor.author	Reddy, N. Ramakrishna
dc.contributor.author	Rao, Y. Srinivasa
dc.date.accessioned	2022-03-27T08:50:35Z
dc.date.available	2022-03-27T08:50:35Z
dc.date.issued	2006-12-18
dc.description.abstract	A practical and an efficient synthesis of three building blocks of tetrahydroisoquinoline alkaloid Ecteinascidin-743 was accomplished, starting from readily available piperonal, 2-methyl anisole, and veratraldehyde. A combination of Vilsmeier-Haack reaction and Sharpless asymmetric dihydroxylation was employed for the synthesis of building blocks A and B whereas a Heck reaction in PEG-2000 and aza-Michael reactions were employed for the synthesis of building block C. © 2006 Elsevier Ltd. All rights reserved.
dc.identifier.citation	Tetrahedron. v.62(51)
dc.identifier.issn	00404020
dc.identifier.uri	10.1016/j.tet.2006.09.056
dc.identifier.uri	https://www.sciencedirect.com/science/article/abs/pii/S0040402006015237
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/11918
dc.subject	Aza-Michael reaction
dc.subject	Baeyer-Villiger reaction
dc.subject	Ecteinascidin-743
dc.subject	Heck reaction
dc.subject	Tetrahydroisoquinolines
dc.title	Synthetic studies on Ecteinascidin-743: synthesis of building blocks through Sharpless asymmetric dihydroxylation and aza-Michael reactions
dc.type	Journal. Article
dspace.entity.type

Now showing 1 - 1 of 1