The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain
The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain
| dc.contributor.author | Tammineni, Prasad | |
| dc.contributor.author | Anugula, Chandrashekhar | |
| dc.contributor.author | Mohammed, Fareed | |
| dc.contributor.author | Anjaneyulu, Murari | |
| dc.contributor.author | Larner, Andrew C. | |
| dc.contributor.author | Sepuri, Naresh Babu Venkata | |
| dc.date.accessioned | 2022-03-27T04:52:08Z | |
| dc.date.available | 2022-03-27T04:52:08Z | |
| dc.date.issued | 2013-02-15 | |
| dc.description.abstract | Background: Apart from its mitochondrial localization, mechanistic details of STAT3 import and assembly in mitochondria remain elusive. Results: Using an in vitro import assay, we show that STAT3 associates with the mitochondrial inner membrane in a GRIM-19-dependent manner. Conclusion: GRIM-19 chaperones the recruitment of STAT3 into mitochondrial inner membrane complexes. Significance: This study identifies a novel function of GRIM-19 and a mechanism for STAT3 import into mitochondria.© 2013 by The American Society for Biochemistry and Molecular Biology, Inc. | |
| dc.identifier.citation | Journal of Biological Chemistry. v.288(7) | |
| dc.identifier.issn | 00219258 | |
| dc.identifier.uri | 10.1074/jbc.M112.378984 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0021925820462751 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/7331 | |
| dc.title | The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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