Temozolomide hydrochloride dihydrate
Temozolomide hydrochloride dihydrate
| dc.contributor.author | Babu, N. Jagadeesh | |
| dc.contributor.author | Sanphui, Palash | |
| dc.contributor.author | Nath, Naba K. | |
| dc.contributor.author | Khandavilli, U. B.Rao | |
| dc.contributor.author | Nangia, Ashwini | |
| dc.date.accessioned | 2022-03-27T09:26:13Z | |
| dc.date.available | 2022-03-27T09:26:13Z | |
| dc.date.issued | 2013-01-28 | |
| dc.description.abstract | The X-ray crystal structure of temozolomide hydrochloride shows that the dihydrate salt contains one neutral temozolomide, one temozolomide-H +Cl-, one H3O+·Cl -, and three water molecules. This is the first crystallographic evidence of a protonated form of the antitumour drug temozolomide. The protonation of water O and imidazole N of the drug are rationalized by calculated pKas. © 2013 The Royal Society of Chemistry. | |
| dc.identifier.citation | CrystEngComm. v.15(4) | |
| dc.identifier.uri | 10.1039/c2ce26528a | |
| dc.identifier.uri | http://xlink.rsc.org/?DOI=C2CE26528A | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/12902 | |
| dc.title | Temozolomide hydrochloride dihydrate | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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