Enhanced production of LTB<inf>4</inf> and free radicals in rat lung by exhaustive physical exercise

dc.contributor.author	Charles Kumar, T.
dc.contributor.author	Veera Reddy, K.
dc.contributor.author	Anuradha, D.
dc.contributor.author	Reddanna, P.
dc.date.accessioned	2022-03-27T00:57:23Z
dc.date.available	2022-03-27T00:57:23Z
dc.date.issued	1997-03-01
dc.description.abstract	Leukotrienes formed by the action of 5-lipoxygenase on arachidonic acid are a group of endogenous compounds active in hypersensitivity reactions and inflammation. In this report the formation of LTB4 from LTA4 was measured by incubating lung microsomes from normal and exercised rats to determine whether LTB4 may have a role in the mediation of exercise-induced oxidant stress. Exhaustive exercise in the form of swimming results in the enhanced production of LTB4 in lung microsomes. Further, flee radicals measured by ESR spectroscopy were also significantly increased in lung tissue from exercised rats. These results suggest a role for LTB4 in the mediation of lung tissue damage during exercise-induced oxidative stress.
dc.identifier.citation	Biochemistry and Molecular Biology International. v.41(3)
dc.identifier.issn	10399712
dc.identifier.uri	http://link.springer.com/10.1023/A:1008638608639
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/3396
dc.subject	Exercise
dc.subject	Free radicals
dc.subject	LTB 4
dc.subject	Lung
dc.title	Enhanced production of LTB<inf>4</inf> and free radicals in rat lung by exhaustive physical exercise
dc.type	Journal. Article
dspace.entity.type

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