Synthesis of [2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6- carbonyl)-1H-indol-3-yl]acetic acids as potential COX-2 inhibitors
Synthesis of [2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6- carbonyl)-1H-indol-3-yl]acetic acids as potential COX-2 inhibitors
| dc.contributor.author | Dubey, P. K. | |
| dc.contributor.author | Kumar, T. Venkateshwar | |
| dc.contributor.author | Reddanna, P. | |
| dc.contributor.author | Kumar, K. Anil | |
| dc.date.accessioned | 2022-03-27T00:57:17Z | |
| dc.date.available | 2022-03-27T00:57:17Z | |
| dc.date.issued | 2006-09-01 | |
| dc.description.abstract | The synthesis of potential COX-2 inhibitors by means of internal Michael addition of ortho toluenesulfonylaminophenyl acrylic acid methyl esters 5a-d with 6-(chloroacetyl)-2H-1,4-bezoxazin-4H-ones 6a-c followed by hydrolysis resulting in the formation of [2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6- carbonyl)-1H-indol-3-yl]acetic acids 1a-k are reported. | |
| dc.identifier.citation | Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry. v.45(9) | |
| dc.identifier.issn | 03764699 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0890623806000645 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/3357 | |
| dc.subject | Acrylic acid methylester | |
| dc.subject | Benzoxazinone | |
| dc.subject | COX-2 inihibitors | |
| dc.subject | Indole acetic acid | |
| dc.subject | Inflammation | |
| dc.title | Synthesis of [2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6- carbonyl)-1H-indol-3-yl]acetic acids as potential COX-2 inhibitors | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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