Formal total synthesis of (-)-spongidepsin

dc.contributor.author	Chandrasekhar, S.
dc.contributor.author	Yaragorla, S. R.
dc.contributor.author	Sreelakshmi, L.
dc.contributor.author	Reddy, Ch Raji
dc.date.accessioned	2022-03-27T08:50:25Z
dc.date.available	2022-03-27T08:50:25Z
dc.date.issued	2008-05-26
dc.description.abstract	The formal total synthesis of (-)-spongidepsin is described. Three fragments I, II, and III were first prepared from readily available starting materials and then assembled to the target compound. The key steps involved in the synthesis are asymmetric α-hydroxylation, Ender's alkylation, and ring-closing metathesis reactions. An alternative route for the fragment II is also achieved involving Sharpless asymmetric epoxidation and Gilman's alkylation as key reactions. © 2008 Elsevier Ltd. All rights reserved.
dc.identifier.citation	Tetrahedron. v.64(22)
dc.identifier.issn	00404020
dc.identifier.uri	10.1016/j.tet.2008.03.041
dc.identifier.uri	https://www.sciencedirect.com/science/article/abs/pii/S0040402008005541
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/11912
dc.subject	d-Proline
dc.subject	Enders auxiliary
dc.subject	Gilman's alkylation
dc.subject	RCM
dc.subject	Sharpless asymmetric epoxidation
dc.subject	Spongidepsin
dc.title	Formal total synthesis of (-)-spongidepsin
dc.type	Journal. Article
dspace.entity.type

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