Synthesis of chiral α-diarylacetic esters by stereospecific 1,2-aryl migration promoted by in situ generated acetals from benzoins
Synthesis of chiral α-diarylacetic esters by stereospecific 1,2-aryl migration promoted by in situ generated acetals from benzoins
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Date
2014-03-07
Authors
Kothapalli, Raveendra Babu
Niddana, Ramana
Balamurugan, Rengarajan
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Abstract
A simple protocol for the synthesis of α-diarylacetic esters from benzoins is described. In situ generated acetal assists rapid 1,2-aryl migration in a stereospecific manner, paving the way to make enantioenriched α-diarylacetic esters from easily accessible enantiopure benzoins. © 2014 American Chemical Society.
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Organic Letters. v.16(5)