Total Synthesis of Pseudellone C

Abstract

The first chemical synthesis of a bisindole alkaloid, pseudellone C, was achieved in 44 % overall yield. The highlighting features of the synthesis include the fact that it is protecting-group free, economic and commercially available starting materials are used, and the pure product can be obtained on a gram scale through one single purification process. The key step of this synthesis is the formation of an amide bond between the two major cores of the natural product.