Oxidative Functionalization of Cyclic N -Arylamines with Nitromethane and TMSCN Using the T-HYDRO/ t -BuOK System

dc.contributor.author	Rao, Gunda Ananda
dc.contributor.author	Periasamy, Mariappan
dc.date.accessioned	2022-03-27T09:06:26Z
dc.date.available	2022-03-27T09:06:26Z
dc.date.issued	2018-02-01
dc.description.abstract	Tertiary cyclic N -arylamines react with nitromethane in the presence of the tert -butyl hydroperoxide (T-HYDRO)/ t -BuOK system to give β-nitroamines in up to 90% yield. When TMSCN is used in place of nitromethane, α-aminonitriles are obtained in up to 96% yield. The method is suitable for several unactivated cyclic arylamine substrates. These transformations are rationalized considering the formation of the corresponding iminium ion intermediates via an initial electron transfer process.
dc.identifier.citation	Synthesis (Germany). v.50(3)
dc.identifier.issn	00397881
dc.identifier.uri	10.1055/s-0036-1590943
dc.identifier.uri	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1590943
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/12425
dc.subject	enamines
dc.subject	iminium ions
dc.subject	N -arylamines
dc.subject	α-aminonitriles
dc.subject	β-nitroamines
dc.title	Oxidative Functionalization of Cyclic N -Arylamines with Nitromethane and TMSCN Using the T-HYDRO/ t -BuOK System
dc.type	Journal. Article
dspace.entity.type

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