Synthesis of Propargylamines via Michael Addition Using Methyl Vinyl Ketone Derivatives, 1-Alkynes, and Secondary Amines Catalyzed by Copper (I) Halides
Synthesis of Propargylamines via Michael Addition Using Methyl Vinyl Ketone Derivatives, 1-Alkynes, and Secondary Amines Catalyzed by Copper (I) Halides
| dc.contributor.author | Udaykumar, Bantu | |
| dc.contributor.author | Periasamy, Mariappan | |
| dc.date.accessioned | 2022-03-27T09:06:24Z | |
| dc.date.available | 2022-03-27T09:06:24Z | |
| dc.date.issued | 2019-12-17 | |
| dc.description.abstract | Propargylamines are synthesized from methyl vinyl ketone derivatives, 1-alkynes, and secondary amines catalyzed by Cu salts involving the Michael addition of amine followed by an unusual C-C bond cleavage and addition of metal acetylides formed in situ to iminium ions. In this approach, the di-, tri-, and tetrasubstituted propargylamines are synthesized in 46-98% yields. | |
| dc.identifier.citation | ACS Omega. v.4(25) | |
| dc.identifier.uri | 10.1021/acsomega.9b03428 | |
| dc.identifier.uri | https://pubs.acs.org/doi/10.1021/acsomega.9b03428 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/12424 | |
| dc.title | Synthesis of Propargylamines via Michael Addition Using Methyl Vinyl Ketone Derivatives, 1-Alkynes, and Secondary Amines Catalyzed by Copper (I) Halides | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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