Convenient method for the synthesis of chiral α,α-diphenyl-2-pyrrolidinemethanol
Convenient method for the synthesis of chiral α,α-diphenyl-2-pyrrolidinemethanol
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Date
1993-06-04
Authors
Bhaskar Kanth, J. V.
Periasamy, Mariappan
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Abstract
A simplified, convenient synthesis of chiral α,α-diphenyl-2-pyrrolidine-methanol involving one step N-and O-protection of S-proline using ethylchloroformate followed by Grignard addition-alkaline hydrolysis (KOH/CH3OH) is described. © 1993.
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Citation
Tetrahedron. v.49(23)