Sulfoximine-directed ruthenium-catalyzed ortho -C-H Alkenylation of (Hetero)Arenes: Synthesis of EP3 receptor antagonist analogue
Sulfoximine-directed ruthenium-catalyzed ortho -C-H Alkenylation of (Hetero)Arenes: Synthesis of EP3 receptor antagonist analogue
| dc.contributor.author | Yadav, M. Ramu | |
| dc.contributor.author | Rit, Raja K. | |
| dc.contributor.author | Shankar, Majji | |
| dc.contributor.author | Sahoo, Akhila K. | |
| dc.date.accessioned | 2022-03-27T08:33:57Z | |
| dc.date.available | 2022-03-27T08:33:57Z | |
| dc.date.issued | 2014-07-03 | |
| dc.description.abstract | The reusable sulfoximine directing-group-assisted Ru(II)-catalyzed chemo- and regioselective ortho-C-H alkenylation of arenes and heteroarenes with acrylates and α,β-unsaturated ketones/vinyl sulfone is shown. The N-aroyl sulfoximine undergoes annulation with diphenylacetylene, delivering isoquinolinones and methyl phenyl sulfoxide. The present protocol is successfully employed for the synthesis of the EP3 receptor antagonist analogue. © 2014 American Chemical Society. | |
| dc.identifier.citation | Journal of Organic Chemistry. v.79(13) | |
| dc.identifier.issn | 00223263 | |
| dc.identifier.uri | 10.1021/jo5008465 | |
| dc.identifier.uri | https://pubs.acs.org/doi/10.1021/jo5008465 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/10838 | |
| dc.title | Sulfoximine-directed ruthenium-catalyzed ortho -C-H Alkenylation of (Hetero)Arenes: Synthesis of EP3 receptor antagonist analogue | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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