Bcr-Abl-independent mechanism of resistance to imatinib in K562 cells: Induction of cyclooxygenase-2 (COX-2) by histone deacetylases (HDACs)

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dc.contributor.author Kalle, Arunasree M.
dc.contributor.author Sachchidanand, Sachchidanand
dc.contributor.author Pallu, Reddanna
dc.date.accessioned 2022-03-27T01:02:24Z
dc.date.available 2022-03-27T01:02:24Z
dc.date.issued 2010-09-01
dc.description.abstract Our previous studies have shown that overexpression of MDR1 and cyclooygenase-2 (COX-2) resulted in resistance development to imatinib in chronic myelogenous leukemia (CML) K562 (IR-K562) cells. In the present study, the regulatory mechanism of MDR1 induction by COX-2 was investigated. A gradual overexpression of MDR1 and COX-2 during the process of development was observed. Furthermore, down regulation of MDR1 upon COX-2 knockdown by siRNA showed a decrease in the PKC levels and activation of PKC by addition of PGE2 to K562 cells, suggesting a role for PKC in the COX-2 mediated induction of MDR1. The present study demonstrates COX-2 induction by HDACs and MDR1 induction by COX-2 via PGE2-cAMP-PKC-mediated pathway. © 2010 Elsevier Ltd.
dc.identifier.citation Leukemia Research. v.34(9)
dc.identifier.issn 01452126
dc.identifier.uri 10.1016/j.leukres.2010.01.030
dc.identifier.uri https://www.sciencedirect.com/science/article/abs/pii/S0145212610000615
dc.identifier.uri https://dspace.uohyd.ac.in/handle/1/3952
dc.subject Bax
dc.subject Bcl2
dc.subject COX-2
dc.subject CREB
dc.subject HDACs
dc.subject Imatinib-resistant K562 cells
dc.subject MDR1
dc.title Bcr-Abl-independent mechanism of resistance to imatinib in K562 cells: Induction of cyclooxygenase-2 (COX-2) by histone deacetylases (HDACs)
dc.type Journal. Article
dspace.entity.type
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