Synthesis, crystal structure and cytotoxicity studies of cis-dichloro(4,5-diazafluoren-9-one)platinum(II)
Synthesis, crystal structure and cytotoxicity studies of cis-dichloro(4,5-diazafluoren-9-one)platinum(II)
| dc.contributor.author | Biju, A. R. | |
| dc.contributor.author | Rajasekharan, M. V. | |
| dc.contributor.author | Bhat, Satish S. | |
| dc.contributor.author | Khan, Ayesha A. | |
| dc.contributor.author | Kumbhar, Avinash S. | |
| dc.date.accessioned | 2022-03-27T09:15:07Z | |
| dc.date.available | 2022-03-27T09:15:07Z | |
| dc.date.issued | 2014-11-01 | |
| dc.description.abstract | cis-Pt(dafone)Cl2 has been synthesized and crystallographically characterized. Dafone, in spite of its long chelate bite, binds in a symmetrical fashion with longer Pt-N distances compared to its phen (1,10-phenanthroline) and bipy (2,2′-bipyridine) analogs. The covalent binding of the complex with DNA was explored by absorption and emission spectroscopy, and electrophoretic mobility shift assay. Cytotoxicity studies of the complex against human cervical carcinoma cells (HeLa) and immortal human keratinocyte (HaCat) cell lines indicate that it has an activity comparable to that of the famed drug, cis-platin. | |
| dc.identifier.citation | Inorganica Chimica Acta. v.423(PB) | |
| dc.identifier.issn | 00201693 | |
| dc.identifier.uri | 10.1016/j.ica.2014.09.007 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0020169314005611 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/12650 | |
| dc.subject | 4,5-diazafluoren-9-one | |
| dc.subject | Cis-platin analog | |
| dc.subject | Covalent binding | |
| dc.subject | Cytotoxicity | |
| dc.subject | DNA | |
| dc.title | Synthesis, crystal structure and cytotoxicity studies of cis-dichloro(4,5-diazafluoren-9-one)platinum(II) | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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