Transition Metal-Free Cascade Cyclization of Epoxy-Ynamides: To Go for 1,3-Oxazines or 1,4-Oxazines?
Transition Metal-Free Cascade Cyclization of Epoxy-Ynamides: To Go for 1,3-Oxazines or 1,4-Oxazines?
| dc.contributor.author | Siva Kumari, A. Leela | |
| dc.contributor.author | Siva Reddy, Alla | |
| dc.contributor.author | Swamy, K. C.Kumara | |
| dc.date.accessioned | 2022-03-27T09:48:40Z | |
| dc.date.available | 2022-03-27T09:48:40Z | |
| dc.date.issued | 2016-11-04 | |
| dc.description.abstract | An approach to both 1,3- and 1,4-oxazines is developed by the cascade cyclization of epoxy ynamides under transition metal-free conditions. Thus, while 1,3-oxazines are obtained in a regio- and stereoselective manner by using base, cyclization of epoxy ynamides with sodium azide as a nucleophile results in 1,4-oxazines. Deuterium-labeling experiment demonstrates the role of water as a proton source in the formation of 1,4-oxazines. Epoxy tethered alkyne precursors provide 1,4-oxazines that undergo click reaction. | |
| dc.identifier.citation | Organic Letters. v.18(21) | |
| dc.identifier.issn | 15237060 | |
| dc.identifier.uri | 10.1021/acs.orglett.6b03047 | |
| dc.identifier.uri | https://pubs.acs.org/doi/10.1021/acs.orglett.6b03047 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/13329 | |
| dc.title | Transition Metal-Free Cascade Cyclization of Epoxy-Ynamides: To Go for 1,3-Oxazines or 1,4-Oxazines? | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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