A simple method of synthesis of (±)-2,3-diarylpiperazines and a novel method of resolution of (±)-2,3-diphenylpiperazine
A simple method of synthesis of (±)-2,3-diarylpiperazines and a novel method of resolution of (±)-2,3-diphenylpiperazine
| dc.contributor.author | Vairaprakash, Pothiappan | |
| dc.contributor.author | Periasamy, Mariappan | |
| dc.date.accessioned | 2022-03-27T09:08:25Z | |
| dc.date.available | 2022-03-27T09:08:25Z | |
| dc.date.issued | 2006-04-28 | |
| dc.description.abstract | Intramolecular reductive coupling of diimines in the presence of Zn/Ti(OiPr)2Cl2 gives the corresponding (±)-2,3-diarylpiperazines in 73-83% yields with dl/meso ratio > 99%: < 1%. The (±)-2,3-diphenylpiperazine obtained in this way was readily resolved partially using L-(+)-tartaric acid, and the enantiomeric purity was enhanced to > 99% ee via preparation of hydrogen-bonded salt aggregates using oxalic acid. © 2006 American Chemical Society. | |
| dc.identifier.citation | Journal of Organic Chemistry. v.71(9) | |
| dc.identifier.issn | 00223263 | |
| dc.identifier.uri | 10.1021/jo060083n | |
| dc.identifier.uri | https://pubs.acs.org/doi/10.1021/jo060083n | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/12479 | |
| dc.title | A simple method of synthesis of (±)-2,3-diarylpiperazines and a novel method of resolution of (±)-2,3-diphenylpiperazine | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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