Neighboring ortho-hydroxy group directed catalytic asymmetric triple domino reactions of acetaldehyde with (E)-2-(2-nitrovinyl)phenols

dc.contributor.author	Ramachary, Dhevalapally B.
dc.contributor.author	Reddy, P. Srinivasa
dc.contributor.author	Prasad, M. Shiva
dc.date.accessioned	2022-03-27T09:39:43Z
dc.date.available	2022-03-27T09:39:43Z
dc.date.issued	2014-01-01
dc.description.abstract	Herein we demonstrate the utilization of neighboring ortho-hydroxy group participation in the pretransition state of enamine- and iminium-based triple domino reactions for high reactions rates and asymmetric induction. Enantiomerically pure, drug-like chromanes and tetrahydro-6H-benzo[c]chromenes having three to four contiguous stereocenters are synthesized through triple domino Michael/aldol/oxa-Michael reactions catalyzed by (R)-2- {diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine followed by Wittig and Michael/Wittig-Horner reactions from simple precursors under mild conditions. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.identifier.citation	European Journal of Organic Chemistry. v.2014(15)
dc.identifier.issn	1434193X
dc.identifier.uri	10.1002/ejoc.201402182
dc.identifier.uri	https://onlinelibrary.wiley.com/doi/10.1002/ejoc.201402182
dc.identifier.uri	https://dspace.uohyd.ac.in/handle/1/13169
dc.subject	Asymmetric catalysis
dc.subject	Michael addition
dc.subject	Neighboring-group effects
dc.subject	Organocatalysis
dc.subject	Phenols
dc.title	Neighboring ortho-hydroxy group directed catalytic asymmetric triple domino reactions of acetaldehyde with (E)-2-(2-nitrovinyl)phenols
dc.type	Journal. Article
dspace.entity.type

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