Enantioselective Gold(I)-Catalyzed Hydrative Cyclizations of N-Propargyl-ynamides into 3,6-Dihydropyridinones
Enantioselective Gold(I)-Catalyzed Hydrative Cyclizations of N-Propargyl-ynamides into 3,6-Dihydropyridinones
| dc.contributor.author | Febvay, Julie | |
| dc.contributor.author | Sanogo, Youssouf | |
| dc.contributor.author | Retailleau, Pascal | |
| dc.contributor.author | Gogoi, Manash Protim | |
| dc.contributor.author | Sahoo, Akhila K. | |
| dc.contributor.author | Marinetti, Angela | |
| dc.contributor.author | Voituriez, Arnaud | |
| dc.date.accessioned | 2022-03-27T09:44:17Z | |
| dc.date.available | 2022-03-27T09:44:17Z | |
| dc.date.issued | 2019-12-06 | |
| dc.description.abstract | This study discloses the first enantioselective variant of the gold(I)-catalyzed hydrative cyclizations of ynamides, which have been implemented by using bis-gold(I) complexes of chiral diphosphines. Starting from N-propargyl-ynamides and water in the presence of p-toluenesulfonic acid, the cyclization reactions afford N-tosyl-3,6-dihydropyridin-2(1H)-ones in good isolated yields and with high levels of stereocontrol (20 examples, enantiomeric ratios up to 94:6). | |
| dc.identifier.citation | Organic Letters. v.21(23) | |
| dc.identifier.issn | 15237060 | |
| dc.identifier.uri | 10.1021/acs.orglett.9b02644 | |
| dc.identifier.uri | https://pubs.acs.org/doi/10.1021/acs.orglett.9b02644 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/13252 | |
| dc.title | Enantioselective Gold(I)-Catalyzed Hydrative Cyclizations of N-Propargyl-ynamides into 3,6-Dihydropyridinones | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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