Synthesis of small cyclic peptides constrained with 3-(3-aminomethylphenyl) propionic acid linkers using free radical-mediated macrocyclization
Synthesis of small cyclic peptides constrained with 3-(3-aminomethylphenyl) propionic acid linkers using free radical-mediated macrocyclization
| dc.contributor.author | Balraju, V. | |
| dc.contributor.author | Reddy, D. Srinivasa | |
| dc.contributor.author | Periasamy, Mariappan | |
| dc.contributor.author | Iqbal, Javed | |
| dc.date.accessioned | 2022-03-27T09:08:43Z | |
| dc.date.available | 2022-03-27T09:08:43Z | |
| dc.date.issued | 2005-08-01 | |
| dc.description.abstract | In this letter, we report that small peptides (di- and tri-) having a 3-bromobenzyl group at the C-termini and an acryloyl group at the N-termini undergo an efficient Bu3SnH-AIBN mediated intramolecular free radical cyclization to afford cyclic peptides in good yields. We also propose that these cyclizations are occurring via a pre-organized acyclic structure dictated by a reverse turn (γ/β-turn). | |
| dc.identifier.citation | Tetrahedron Letters. v.46(31) | |
| dc.identifier.issn | 00404039 | |
| dc.identifier.uri | 10.1016/j.tetlet.2005.05.115 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0040403905011731 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/12487 | |
| dc.subject | Cyclic peptide | |
| dc.subject | Free radical | |
| dc.subject | Peptidomimetics | |
| dc.title | Synthesis of small cyclic peptides constrained with 3-(3-aminomethylphenyl) propionic acid linkers using free radical-mediated macrocyclization | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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