A convenient enantioselective synthesis of trans-2-aryloxycyclohexan-1-ols using pig liver acetone powder (PLAP) as biocatalyst
A convenient enantioselective synthesis of trans-2-aryloxycyclohexan-1-ols using pig liver acetone powder (PLAP) as biocatalyst
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Date
1995-01-01
Authors
Basavaiah, Deevi
Krishna, Peddinti Rama
Bharathi, Tirumala K.
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Abstract
Pig liver acetone powder (PLAP) has been used as a biocatalyst for enantioselective hydrolysis of racemic trans-1-acetoxy-2-aryloxycyclohexannes to produce the resulting (R,R)-2-aryloxycyclohexan-1-ols upto > 99% enantiomeric purities. (R,R)-Selectivity in this hydrolysis of racemic trans-2-aryloxycyclohexyl acetates was explained on the basis of Jones' three dimensional active site-model. © 1995.
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Tetrahedron: Asymmetry. v.6(2)